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In vitro and in vivo studies in animals have shown that the use of deuterated PUFAs can lower the peroxidation effects on producing atherosclerosis, control hyperlipidaemia, and reduce cholesterol levels in blood (García-Ruiz et al., 2002)

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The reported findings have a certain significance in the light that neurovascular and immune system alterations are mediated by miRNA networks that function as regulators of cellular response to opioids (Grimm et al., 2023)